Vilafinil or Modafinil is one of the most popular drugs of the Smart drugs segment in the West. It is actively used by students, scientists, and other people who want to squeeze the most out of their mental abilities. However, we consider it important to write not only about the positive effects of the drug but also to identify its negative aspects.
Modafinil increases histamine levels
Histamine is a mediator that is produced by the human body and plays an important role in a variety of vital functions and the pathogenesis of various disease states. His most famous role is participation in allergic reactions of the body. However, in the central nervous system, it plays the role of a neurotransmitter, which is involved in the processes of arousal. Therefore, modafinil, raising histamine levels, for example, reduces drowsiness.
Partial blocking of the reuptake of dopamine, glutamate, and norepinephrine with the subsequent strengthening of their production
Drugs like amphetamine and cocaine act in a similar way. The effect is manifested by the fact that a person becomes very collected and concentrated on anything, it will be difficult to distract him with external irritants. But, in contrast to the usual psychostimulants, modafinil has a low potential for serious abuse and does not develop addiction among those who first used it.
Suppression of GABA secretion
Gamma-aminobutyric acid is the most important inhibitory mediator of the central nervous system. Its suppression leads to a decrease in central inhibition processes. As a result, a decrease in GABAergic tone leads to an increase in dopamine levels.
One of the not fully studied effects. IQ level is associated with acetylcholine, but modafinil does not act on it or almost does not act. Therefore, it is not known how this drug improves the functioning of the brain and its cognitive functions. It is possible that after a long period of time this may lead to any side effects.
Side effects of Vilafinil
Whatever positive properties modafinil possesses, its side effects are quite significant. They are found relatively more often than most other nootropics, but it should be noted that the effectiveness of modafinil on their background is stronger.
The most common side effect is a headache?? 34% of all side effects. Also, the danger is a strong depletion of the body. Regular lack of sleep, which is stopped by taking modafinil, leads to serious imbalances and imbalances in the body. Other side effects include insomnia, nausea, diarrhea, dyspeptic disorders, back pain, anxiety, anxiety, fever, shortness of breath, yellowing of the skin and sclera, darkening of the urine.