Tamoxifen is a hormone therapy used to treat hormone receptor-positive breast cancer. It can greatly reduce the risk of cancer recurrence (return) and invasive cancer. Some people take tamoxifen to lower the risk of developing breast cancer.

Tamoxifen is a selective estrogen receptor modulator (SERM). It is often used as a post-cycle therapy drug or an anti-estrogen by bodybuilders and athletes. The steroid users will not be concerned about the specific side effects of using Tamoxifen as it is responsible for targeting certain body parts

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Tamoxifen improved the structure of leg muscles and diminished cardiac fibrosis by~ 50%. Tamoxifen also reduced fibrosis in the diaphragm, while increasing its thickness,myofiber count, and myofiber diameter, thereby augmenting by 72% the amount of contractile tissue available for respiratory function.
Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy.
Tamoxifen treatment for 5 days decreases fat mass for as long as 18 weeks in mice fed HFD. Tamoxifen alters mRNA levels of some genes involved in lipid metabolism in white adipose tissue and improves glucose and insulin tolerance as well as hepatic insulin signaling for 12–20 weeks.