Letrozole is a medicine used for treating breast cancer. It can also help prevent breast cancer coming back. It is mainly prescribed for women who have been through the menopause and have a type of cancer called “hormone-dependent” breast cancer.

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Conclusions: Letrozole improves sperm concentration and increases testosterone-oestradiol ratio for men with oligozoospermia who have normal testosterone-oestradiol ratio; its role in the treatment of male infertility may be extended to this group of patients
Letrozole is considered a first-choice option for improving fertility in people with PCOS. Letrozole has been shown to work as well, if not better, than clomiphene at stimulating ovulation, as well as leading to successful pregnancies and live births.
The anti-estrogen action of letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids.
Letrozole, an aromatase inhibitor, may be used successfully to enhance sperm characteristics in infertile males with low serum T/E2, allowing for the possibility of fertility in men with oligospermia following therapy